Abstract: Under the promotion for Yangtze River Economic Belt, transforming from the second to the third industry is important. Among all trades, cultural and creative industries are the focus.Hunan Province is in the middle range of Yangtze River Economic Belt, and the development strategy about this economic belt released in 2013 has brought significant opportunities for jewelry industry in Hunan Province. Based on field and literature investigation, the authors discussed the current condition of jewelry industry in Hunan Province and its opportunities and strategies under the strategy frame of Yangtze River Economic Belt in this paper. The economy growth of Hunan Province is comparatively fast. Its GDP growth rate trend matches that of whole nation, which maintains a higher growth rate and lays a good economy foundation for the province. Hunan Province has advantages in natural resource including abundant mineral deposits, geo-parks, etc. It is a world-famous hometown for non-ferrous metal and a currently producing area for mineral specimens and crystals. Hunan Province has a good geographical location, since it is in the center of jewelry industry structure formed by jewelry market in Pearl River Delta represented by Shenzhen and Panyu, Yangtze River Delta represented by Shanghai, Bohai Sea Ring Area represented by Beijing and Yunan jewelry market. The recently successful China (Hunan) Mineral & Gem Show (CMGS) in Hunan Province has promoted world popularity for mineral and crystal specimens. However, jewelry industry in Hunan Province has the following problems:the size of jewelry market in Hunan Province is small, and its gem consumption is still in the traditional preference of gold, diamond and jadeite; the industry chain of jewelry market is not complete; its professional talent is in shortage; its local gem brand is small in scale;its capability for further development is weak and its gem market needs cultivation. Therefore, the authors suggest Hunan Province should focus on the following aspects:(1) government making scientific plans on the jewelry industry development and establishing long-term developing mechanism; (2) launching finance innovation, completing industry chain and promoting industry cluster; (3) strengthening industrial associations integrate industry development resource and making use of folk creative wisdom; (4) bringing in professional talents and technicians and enhancing professional training; (5) breaking the barriers of traditional jewelry industry and promoting the infusion of mineral specimens, viewing stones and cultural innovation.