Abstract: Turquoise is a pillar industry in Zhushan County, Hubei Province. In 2010, "Zhushan Turquoise" has been approved as national geographical indication brand product. In recent years, the local government has continuously increased its support to promote the transformation and upgrading of turquoise industry. Therefore, it is imperative to strengthen the collaborative regulatory role of relevant subjects in the turquoise industry chain. From the perspective of multi synergy, this paper aims at the two important links of raw stone mining and processing in the turquoise industry chain, combining the application background of block chain technology reverse supervision traceability, builds a tripartite evolution game model for the relevant stakeholder government, villagers and turquoise enterprises, and uses python to simulate the evolution process of the game players, to explore the evolution of the game pattern of the tripartite players and its key influencing factors: government-leading, reward and punishment mechanism, blockchain supervision mechanism, and scale and intensive development of turquoise enterprises.