Abstract: Mokume Gane technique has a history of nearly 400 years. Its formation has gone through the joint action of Japan and western countries (the United States, the United Kingdom, Australia), and has experienced tremendous changes and evolution in terms of technology, materials, product coverage and service objects. During the development of Mokume Gane technique, many countries have emerged landmark leaders which diversified the technique in different regions and time periods. Although these changes are slow, they still maintain the development and evolution of this extremely complex technique in depth and breadth. Through the review of the literature at home and abroad, this paper combs the development and changes of the representative schools and key techniques of Mokume Gane technique in the historical development of Edo period in Japan. We strive to restore and reproduce the appearance of the development of Mokume Gane technique in Japan from the rudiment of Edo period to the first climax stage in chronological order, so that the majority of craft lovers can get some inspirations from it, which may promote the popularization of the technique in China, and provide support materials for enriching the language of Chinese contemporary jewelry design.